One of the cool things we can do at Telescope Live is to book Advanced Requests or make suggestions for new One Click Observations. Some would assume that you have to do a named object and leave it centered on that.

Several of PixInsight’s processes use the concept of Wavelet Based Processing to analyze and process astro images. These types of PI processes include: Multiscale Median Transform (MMT)

I imagine you have ran into a problem with uneven illumination or gradients in some of your images, and sometimes those simply will not calibrate all the way out with flats.

PixInsight has a process script called Image Annotation, where all the known objects contained in your image can be identified and labeled.